The principle of the 3Rs in nanomedicine and drug delivery studies


21 Sept.			11:30 - 13:00



HEALTH & NANOMEDICINE
NANOMEDICINE
TT.VI - Technical Multi-Track with Parallel SYMPOSIA
The principle of the 3Rs in nanomedicine and drug delivery studies
Co-organized with ISS, FARVA Chairs: Giuseppina BOZZUTO & Agnese MOLINARI, ISS
Nanomedicine and nano delivery systems represent key research fields due to increasing employment of materials in the nanoscale range as tools to deliver therapeutic or diagnostic agents to specific sites in a controlled manner. Three-dimensional cell culture models, computational/in silico models, -omics technologies, experimental research with animal species with lower neurological development represent useful tools in the advance of preclinical strategies, aimed to assess the ability of nano-based delivery systems to transport and selectively release drugs inside the cell/tissue target. These strategies, avoiding the use of higher vertebrates, comply with the principle of the 3Rs (replacement, reduction, refinement) in scientific research. This workshop will focus on the application of the 3R principle in nanomedicine and drug delivery studies, giving particular attention at the application of new biological assays as well as in vitro 3D cell model and lower organism use.

TT.VI.C.1	Gianluca PANZINI - CV ISS 3Rs implementation and technical-scientific evaluation of research projects involving the use of laboratory animals
TT.VI.C.2	Isabella DE ANGELIS - CV ISS The principle of the 3Rs between past and future
TT.VI.C.3	Cristina ANDREOLI - CV ISS In vitro models for genotoxicity assessment of nanomaterials
TT.VI.C.4	Emily SCHIFANO - CV Sapienza University of Rome Caenorhabditis elegans: a small worm for a small world
TT.VI.C.5	Federica FOGLIETTA - CV Sapienza University of Turin Three-dimensional models for a deep investigation of ultrasound-based anticancer treatments
TT.VI.C.6	Mario CARERE - CV ISS Zebrafish embryos: a model for ecosystem health in compliance with the principle of the 3Rs