Tumor microenvironment on the move: progress and challenges


22 Sept.			14:00 - 15:30



YOUNGINNOVATION		HEALTH & NANOMEDICINE
THE STATE OF RESEARCH COMMUNICATED BY YOUNG RESEARCHERS
TT.XI - Technical Multi-Track with Parallel SYMPOSIA
Tumor microenvironment on the move: progress and challenges
Co-organized with University Magna Graecia of Catanzaro and Sapienza University of Rome Chair: Marilena LANZINO, University of Calabria
Deepening the tumor microenvironment, a complex interplay of cells, signals, and structures, holds the key to unraveling cancer progression and devising targeted therapies. Cellular interactions, immune responses, and extracellular matrix dynamics converge to influence tumor growth and metastasis. Advances in imaging and single-cell analysis provide unprecedented glimpses into this dynamic landscape, paving the way for tailored interventions. However, challenges loom large. The heterogeneous nature of the microenvironment and its adaptive responses pose obstacles to effective treatments. Therapeutic resistance, immune evasion, and the intricate web of interactions demand innovative strategies. As researchers and clinicians navigate this intricate terrain, novel avenues emerge. Targeted therapies, immunomodulation, and precision medicine strategies are being tailored to exploit the vulnerabilities within the tumor microenvironment. Collaborative efforts bridge disciplines, fostering breakthroughs in understanding and interventions. In the quest for progress, the tumor microenvironment offers untold potential. A deeper comprehension promises to usher in an era of personalized treatments, potent combination therapies, and improved patient outcomes, redefining the battle against cancer. Here, the evolving journey through the tumor microenvironment is captured, highlighting progress, acknowledging challenges, and illuminating a trajectory that merges science, technology, and compassion to transform the landscape of cancer care.
*The symposium is part of the Special Event SE.I*
TT.XI.A.1 SE.I.11.1	Introductive Keynote Ines BARONE University of Calabria The weight of obesity in breast cancer: unravelling the molecular links
TT.XI.A.2 SE.I.11.2	Martina VINCENZI - CV Sapienza University of Rome Identification of a novel biomarker of HIF-1alpha-mediated doxorubicin resistance in 3D cancer spheroid models
TT.XI.A.3 SE.I.11.3	Elena SPLENDIANI - CV Sapienza University of Rome Circulating EV-microRNAs in Metastatic Melanoma: from diagnostic to response to treatment biomarkers
TT.XI.A.4 SE.I.11.4	Maria Gioia FABIANO Sapienza University of Rome Inhibiting Pin1 by ATRA-loaded niosomes to treat High-Grade Serous Ovarian Cancer
TT.XI.A.5 SE.I.11.5	Giusy AUGIMERI - CV University of Calabria A hybrid cell population generated through engulfment of mesenchymal stem cell by breast cancer cells enhances chemoresistance and metastasis